Long-term treatment of hypertension with the calcium channel blocker diltiazem
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چکیده
منابع مشابه
Evaluation of Mutagenicity of Mebudipine, a New Calcium Channel Blocker
Mebudipine is a new dihydropyridine calcium channel blocker, synthesized in our laboratory, for treatment of hypertension. It has shown a better efficacy than other drugs in this group. For assessing the risks of this drug, certain safety tests in the preclinical stage have been performed. In this study mutagenic effect of mebudipine was evaluated using Ames assay that could assess the mutageni...
متن کاملEvaluation of Mutagenicity of Mebudipine, a New Calcium Channel Blocker
Mebudipine is a new dihydropyridine calcium channel blocker, synthesized in our laboratory, for treatment of hypertension. It has shown a better efficacy than other drugs in this group. For assessing the risks of this drug, certain safety tests in the preclinical stage have been performed. In this study mutagenic effect of mebudipine was evaluated using Ames assay that could assess the mutageni...
متن کاملThe effect of calcium channel blocker diltiazem on photoreceptor degeneration in the rhodopsin Pro213His rat.
PURPOSE To determine whether the calcium channel blocker D-cis-diltiazem promotes photoreceptor survival in rats with the Pro23His rhodopsin mutation. METHODS Heterozygous Pro23His rhodopsin line 1 rats (n = 11) were treated daily, according to a protocol applied successfully in rd mice, with D-cis-diltiazem hydrochloride increased incrementally from 21 to 54 mg/kg in a divided dose (8 AM and...
متن کاملCalcium-Channel Blocker Overdose
1522-8401/$ see fro doi:10.1016/j.cpem.2 Department of Eme Children’s Hospit RI 02903, USA. Reprint requests and Department of E Children’s Hospit RI 02903, USA. Calcium-channel blockers (CCB) were first developed in the 1960s. Since then, the list of formulations and variety of uses has increased significantly. Unfortunately, toxic exposures to CCBs have also increased since their debut. This ...
متن کاملCalcium channel blocker overdose: Experience with amlodipine
Amlodipine overdose is only scarcely reported from India. We report two cases of near fatal Amlodipine overdose managed in our ICU with fluid, vasopressors, calcium infusion and Glucagon. Literature is reviewed and other treatment modalities discussed.
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ژورنال
عنوان ژورنال: Clinical Cardiology
سال: 1987
ISSN: 0160-9289,1932-8737
DOI: 10.1002/clc.4960100513